Which statement accurately describes a function of Factor H?

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Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

Which statement accurately describes a function of Factor H?

Explanation:
Factor H regulates the alternative pathway by binding to C3b on cell surfaces and acting as a cofactor for Factor I. This pairing enables Factor I to cleave C3b into inactive fragments (iC3b), which cannot support formation of the C3 convertase. By inactivating C3b, Factor H halts further amplification of the complement cascade on host tissues. While Factor H can also influence convertase formation by reducing Factor B binding to C3b, the essential description is its role as a cofactor for Factor I–mediated cleavage of C3b.

Factor H regulates the alternative pathway by binding to C3b on cell surfaces and acting as a cofactor for Factor I. This pairing enables Factor I to cleave C3b into inactive fragments (iC3b), which cannot support formation of the C3 convertase. By inactivating C3b, Factor H halts further amplification of the complement cascade on host tissues. While Factor H can also influence convertase formation by reducing Factor B binding to C3b, the essential description is its role as a cofactor for Factor I–mediated cleavage of C3b.

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