Which of the following would represent a double-negative thymocyte?

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Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

Which of the following would represent a double-negative thymocyte?

Explanation:
Double-negative thymocytes are early T cell precursors in the thymus that have committed to the T cell lineage but have not begun expressing the co-receptors CD4 or CD8. They typically express early T cell markers such as CD2 and CD3, but lack CD4 and CD8. The profile that shows CD2 positivity and CD3 positivity while both CD4 and CD8 are absent fits this stage perfectly. The other profiles have one or both co-receptors present, which means they are at a later stage (double-positive or single-positive) rather than the double-negative stage.

Double-negative thymocytes are early T cell precursors in the thymus that have committed to the T cell lineage but have not begun expressing the co-receptors CD4 or CD8. They typically express early T cell markers such as CD2 and CD3, but lack CD4 and CD8.

The profile that shows CD2 positivity and CD3 positivity while both CD4 and CD8 are absent fits this stage perfectly. The other profiles have one or both co-receptors present, which means they are at a later stage (double-positive or single-positive) rather than the double-negative stage.

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