Which marker characterizes helper T cells (T helper/inducer)?

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Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

Which marker characterizes helper T cells (T helper/inducer)?

Explanation:
Cell surface markers define T cell subsets, and helper T cells are identified by expression of CD4. CD4 acts as a co-receptor that binds MHC class II on antigen-presenting cells and helps coordinate the immune response by aiding B cell antibody production and macrophage activation. This specific association makes CD4 the signature marker for helper T cells. In contrast, CD3 is a complex found on all mature T cells, CD8 marks cytotoxic T cells, and CD11 is an integrin expressed more broadly on leukocytes and is not specific to helper T cells.

Cell surface markers define T cell subsets, and helper T cells are identified by expression of CD4. CD4 acts as a co-receptor that binds MHC class II on antigen-presenting cells and helps coordinate the immune response by aiding B cell antibody production and macrophage activation. This specific association makes CD4 the signature marker for helper T cells. In contrast, CD3 is a complex found on all mature T cells, CD8 marks cytotoxic T cells, and CD11 is an integrin expressed more broadly on leukocytes and is not specific to helper T cells.

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