Selective destruction of Th cells by HIV contributes to immune suppression by which means?

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Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

Selective destruction of Th cells by HIV contributes to immune suppression by which means?

Explanation:
HIV causes immune suppression mainly by reducing the amount of IL-2, the growth factor produced by activated CD4+ T helper cells. IL-2 drives the proliferation and activation of T cells (both helper and cytotoxic), as well as supporting natural killer cell activity. When HIV depletes CD4+ T cells, IL-2 production drops, leading to impaired T-cell expansion and a weaker overall immune response. The other cytokines listed have important roles in inflammation or anti-inflammatory regulation, but they are not the primary drivers of the T-cell–mediated immune suppression caused by HIV.

HIV causes immune suppression mainly by reducing the amount of IL-2, the growth factor produced by activated CD4+ T helper cells. IL-2 drives the proliferation and activation of T cells (both helper and cytotoxic), as well as supporting natural killer cell activity. When HIV depletes CD4+ T cells, IL-2 production drops, leading to impaired T-cell expansion and a weaker overall immune response. The other cytokines listed have important roles in inflammation or anti-inflammatory regulation, but they are not the primary drivers of the T-cell–mediated immune suppression caused by HIV.

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