In congenital toxoplasmosis, which class of antibodies is the most sensitive in detecting infection?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

In congenital toxoplasmosis, which class of antibodies is the most sensitive in detecting infection?

Explanation:
In congenital toxoplasmosis, the newborn’s own immune response is what reveals infection. Maternal antibodies, especially IgG, cross the placenta and can be present in the infant even without infection, so IgG by itself isn’t reliable for diagnosing congenital infection. IgM, on the other hand, does not cross the placenta, so detecting toxoplasma-specific IgM in the newborn indicates that the fetus produced antibodies in response to in utero infection. This makes IgM the most sensitive clue to congenital infection. IgA is not typically used as a reliable indicator in this setting, and IgE isn’t relevant to toxoplasma serology.

In congenital toxoplasmosis, the newborn’s own immune response is what reveals infection. Maternal antibodies, especially IgG, cross the placenta and can be present in the infant even without infection, so IgG by itself isn’t reliable for diagnosing congenital infection. IgM, on the other hand, does not cross the placenta, so detecting toxoplasma-specific IgM in the newborn indicates that the fetus produced antibodies in response to in utero infection. This makes IgM the most sensitive clue to congenital infection. IgA is not typically used as a reliable indicator in this setting, and IgE isn’t relevant to toxoplasma serology.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy