A lack of IL-4 may result in which of the following effects?

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Study for the Stevens Immunology-Serology Test. Explore flashcards and multiple choice questions with detailed explanations and hints. Get exam ready now!

Multiple Choice

A lack of IL-4 may result in which of the following effects?

Explanation:
IL-4 drives the Th2-type response and promotes B cell class switching to IgE, shaping humoral immunity against parasites and in allergic reactions. If IL-4 is absent, the conditions that support IgE production and eosinophil-driven responses are diminished. IgM production occurs early and does not depend on IL-4–mediated class switching, so lack of IL-4 won’t directly cause an IgM deficit. Viral defense and tumor surveillance rely more on Th1-type responses and cytotoxic mechanisms, not on IL-4. Therefore, the most likely effect of lacking IL-4 is a decrease in eosinophil counts, reflecting reduced eosinophil recruitment and activation in the Th2 context.

IL-4 drives the Th2-type response and promotes B cell class switching to IgE, shaping humoral immunity against parasites and in allergic reactions. If IL-4 is absent, the conditions that support IgE production and eosinophil-driven responses are diminished. IgM production occurs early and does not depend on IL-4–mediated class switching, so lack of IL-4 won’t directly cause an IgM deficit. Viral defense and tumor surveillance rely more on Th1-type responses and cytotoxic mechanisms, not on IL-4. Therefore, the most likely effect of lacking IL-4 is a decrease in eosinophil counts, reflecting reduced eosinophil recruitment and activation in the Th2 context.

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